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  • News bot Jan. 29, 2026, 8:53 p.m.

    📋 Ionis Pharmaceuticals Inc (IONS) - Clinical Trial Update

    Filing Date: 2026-01-12

    Accepted: 2026-01-12 07:00:46

    Event Type: Clinical Trial Update

    Event Details:

    Ionis Pharmaceuticals Inc (IONS) Announces Clinical Trial Update Ionis Pharmaceuticals Inc (IONS) provided an update on its clinical development programs. Clinical Development Highlights:
    • Drug Program: bepirovirsen, launch
    • Diseases/Conditions: chronic hepatitis B, severe hypertriglyceridemia
    • Clinical Stage: Phase 3, Phase 3 program
    • Collaboration: FDA
      • expected in 2026
      • expected in H2 2026
      • expected in H1 2026

    🔬 Clinical Development Pipeline (Ionis Pharmaceuticals Inc):

    Product Type Development Stage Therapeutic Area Source
    Olezarsen DRUG Phase PHASE3 Familial Chylomicronemia Syndrome ClinicalTrials.gov
    Pelacarsen DRUG Phase PHASE1 Healthy Participants ClinicalTrials.gov
    ION582 DRUG Phase PHASE3 Angelman Syndrome ClinicalTrials.gov
    Placebo DRUG Phase PHASE3 Amyotrophic Lateral Sclerosis ClinicalTrials.gov
    Donidalorsen DRUG Phase PHASE3 Hereditary Angioedema (HAE) ClinicalTrials.gov
    zilganersen DRUG Phase PHASE3 Alexander Disease ClinicalTrials.gov
    Eplontersen DRUG Phase PHASE3 Transthyretin-Mediated Amyloid Cardiomyopathy (ATTR CM) ClinicalTrials.gov
    ION363 DRUG Phase PHASE3 Amyotrophic Lateral Sclerosis ClinicalTrials.gov
    sapablursen DRUG Phase PHASE2 Phlebotomy Dependent Polycythemia Vera ClinicalTrials.gov
    ION356 DRUG Phase PHASE1 Pelizaeus-Merzbacher Disease ClinicalTrials.gov
    ION464 DRUG Phase PHASE1 Multiple System Atrophy ClinicalTrials.gov
    Sham procedure PROCEDURE Phase PHASE1 Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome ClinicalTrials.gov
    ION440 DRUG Phase PHASE1 Methyl CpG Binding Protein 2 (MECP2) Duplication Syndrome ClinicalTrials.gov
    BIIB094 DRUG Phase PHASE1 Parkinson's Disease ClinicalTrials.gov
    Fomivirsen sodium DRUG Phase PHASE2 Cytomegalovirus Retinitis ClinicalTrials.gov
    ISIS 113715 DRUG Phase PHASE1 Type 2 Diabetes Mellitus ClinicalTrials.gov
    Ganciclovir DRUG Phase PHASE2 Cytomegalovirus Retinitis ClinicalTrials.gov
    ISIS 2503 DRUG Phase PHASE2 Pancreatic Cancer ClinicalTrials.gov
    ISIS 353512 DRUG Phase PHASE1 Inflammatory Diseases ClinicalTrials.gov
    ISIS 325568 DRUG Phase PHASE1 Type 2 Diabetes Mellitus ClinicalTrials.gov
    ISIS 388626 DRUG Phase PHASE1 Type 2 Diabetes Mellitus ClinicalTrials.gov
    ISIS 333611 DRUG Phase PHASE1 Familial Amyotrophic Lateral Sclerosis ClinicalTrials.gov
    ISIS CRP Rx or Placebo DRUG Phase PHASE2 Rheumatoid Arthritis ClinicalTrials.gov
    mipomersen DRUG Phase PHASE2 Metabolic Diseases ClinicalTrials.gov
    Mipomersen Sodium DRUG Phase PHASE3 Lipid Metabolism, Inborn Errors ClinicalTrials.gov
    mipomersen sodium; warfarin sodium DRUG Phase PHASE1 Healthy ClinicalTrials.gov
    warfarin sodium DRUG Phase PHASE1 Healthy ClinicalTrials.gov
    Isis 420915/GSK 299872 DRUG Phase PHASE2 Amyloidosis ClinicalTrials.gov
    Enoxaparin DRUG Phase PHASE2 Venous Thromboembolism ClinicalTrials.gov
    ISIS-FXIRx Dose #3 DRUG Phase PHASE2 Venous Thromboembolism ClinicalTrials.gov
    ISIS-FXIRx Dose #2 DRUG Phase PHASE2 Venous Thromboembolism ClinicalTrials.gov
    ISIS-GCCRRx DRUG Phase PHASE2 Type 2 Diabetes Mellitus ClinicalTrials.gov
    ISIS 301012 or Placebo DRUG Phase PHASE2 Hypercholesterolemia ClinicalTrials.gov
    ISIS 301012 DRUG Phase PHASE2 Hypercholesterolemia, Familial ClinicalTrials.gov
    daily OAD (metformin and/or sulfonylurea) DRUG Phase PHASE2 Type 2 Diabetes Mellitus ClinicalTrials.gov
    ISIS-PTP1BRx DRUG Phase PHASE2 Type 2 Diabetes Mellitus ClinicalTrials.gov
    ISIS-GCGRRx - Dose Level 2 DRUG Phase PHASE2 Type 2 Diabetes Mellitus ClinicalTrials.gov
    ISIS-GCGRRx - Dose Level 1 DRUG Phase PHASE2 Type 2 Diabetes Mellitus ClinicalTrials.gov
    ISIS CRP Rx DRUG Phase PHASE2 Paroxysmal Atrial Fibrillation ClinicalTrials.gov
    moxifloxacin hydrochloride (Avelox®) DRUG Phase PHASE1 Healthy ClinicalTrials.gov
    ISIS-GCGRRx DRUG Phase PHASE2 Type 2 Diabetes ClinicalTrials.gov
    Ionis AGT-LRx DRUG Phase PHASE1 Healthy Volunteers ClinicalTrials.gov
    Placebo Comparator DRUG Phase PHASE1 Elevated Triglycerides (TG) ClinicalTrials.gov
    APOC-III-L-Rx DRUG Phase PHASE1 Elevated Triglycerides (TG) ClinicalTrials.gov
    IONIS-STAT3Rx DRUG Phase PHASE1 Advanced Cancers ClinicalTrials.gov
    Carboplatin DRUG Phase PHASE1 Non-small Cell Lung Cancer ClinicalTrials.gov
    Paclitaxel DRUG Phase PHASE1 Non-small Cell Lung Cancer ClinicalTrials.gov
    ISIS EIF4E Rx DRUG Phase PHASE1 Non-small Cell Lung Cancer ClinicalTrials.gov
    ISIS-FGFR4RX DRUG Phase PHASE2 Obesity ClinicalTrials.gov
    ISIS 416858 DRUG Phase PHASE2 End-stage Renal Disease (ESRD) ClinicalTrials.gov
    ISIS-GCGRRx- Dose Level 2 DRUG Phase PHASE2 Type 2 Diabetes ClinicalTrials.gov
    ISIS-GCGRRx- Dose Level 1 DRUG Phase PHASE2 Type 2 Diabetes ClinicalTrials.gov
    Sterile Normal Saline (0.9% NaCl) DRUG Phase PHASE1 Elevated Lipoprotein(a) ClinicalTrials.gov
    IONIS-APO(a)-LRx DRUG Phase PHASE1 Elevated Lipoprotein(a) ClinicalTrials.gov
    Placebo (sterline saline 0.9%) DRUG Phase PHASE2 Geographic Atrophy ClinicalTrials.gov
    IONIS-FB-Lrx DRUG Phase PHASE2 Geographic Atrophy ClinicalTrials.gov
    ISIS 681257 DRUG Phase PHASE1 Renal Impairment ClinicalTrials.gov
    AKCEA-ANGPTL3-LRX DRUG Phase PHASE2 Homozygous Familial Hypercholesterolemia ClinicalTrials.gov
    IONIS-PKKRx (ISIS 546254) DRUG Phase PHASE2 Chronic Migraine ClinicalTrials.gov
    ISIS-APO(a)Rx DRUG Phase PHASE2 Elevated Lipoprotein(a) ClinicalTrials.gov
    IONIS TMPRSS6-Lrx DRUG Phase PHASE1 Thalassemia ClinicalTrials.gov
    Inotersen DRUG Phase PHASE2 FAP ClinicalTrials.gov
    IONIS DGAT2Rx DRUG Phase PHASE2 Hepatic Steatosis ClinicalTrials.gov
    ISIS 443139 120 mg DRUG Phase PHASE1 Huntington's Disease ClinicalTrials.gov
    ISIS 443139 90 mg DRUG Phase PHASE1 Huntington's Disease ClinicalTrials.gov
    ISIS 443139 60 mg DRUG Phase PHASE1 Huntington's Disease ClinicalTrials.gov
    ISIS 443139 30 mg DRUG Phase PHASE1 Huntington's Disease ClinicalTrials.gov
    ISIS 443139 10 mg DRUG Phase PHASE1 Huntington's Disease ClinicalTrials.gov
    IONIS-ENaCRx DRUG Phase PHASE1 Healthy Subjects ClinicalTrials.gov
    ISIS 703802 20 mg DRUG Phase PHASE2 NAFLD ClinicalTrials.gov
    ISIS 703802 80 mg DRUG Phase PHASE2 NAFLD ClinicalTrials.gov
    ISIS 703802 40 mg DRUG Phase PHASE2 NAFLD ClinicalTrials.gov
    IONIS ANGPTL3-LRx DRUG Phase PHASE1 Hypertriglyceridemia ClinicalTrials.gov
    Volanesorsen DRUG Phase PHASE3 Familial Chylomicronemia Syndrome ClinicalTrials.gov
    IONIS-HBVRx DRUG Phase PHASE2 Hepatitis B ClinicalTrials.gov
    Moxifloxacin DRUG Phase PHASE1 Abnormalities, Cardiovascular ClinicalTrials.gov
    ISIS apoC-III Rx DRUG Phase PHASE2 Hypertriglyceridemia ClinicalTrials.gov
    ION904 DRUG Phase PHASE1 Healthy Volunteers ClinicalTrials.gov
    Alicaforsen DRUG Phase PHASE3 Crohn's Disease ClinicalTrials.gov
    ION547 DRUG Phase PHASE1 Healthy Volunteers ClinicalTrials.gov
    IONIS FXI-LRx DRUG Phase PHASE1 Healthy Participants ClinicalTrials.gov
    ISIS-APOCIIIRX DRUG Phase PHASE2 Type 2 Diabetes ClinicalTrials.gov
    Normal Saline DRUG Phase PHASE2 Covid19 ClinicalTrials.gov
    ISIS 721744 DRUG Phase PHASE2 Covid19 ClinicalTrials.gov
    ISIS 757456 DRUG Phase PHASE2 Mild Hypertension ClinicalTrials.gov
    ISIS 104838 DRUG Phase PHASE2 Rheumatoid Arthritis ClinicalTrials.gov
    ION-827359 DRUG Phase PHASE2 Chronic Bronchitis ClinicalTrials.gov
    ISIS 678354 DRUG Phase PHASE2 Hypertriglyceridemia ClinicalTrials.gov
    ISIS 3521 BIOLOGICAL Phase PHASE3 Lung Cancer ClinicalTrials.gov
    ION537 DRUG Phase PHASE1 Advanced Solid Tumors ClinicalTrials.gov
    ISIS 14803 DRUG Phase PHASE2 Hepatitis C, Chronic ClinicalTrials.gov
    IONIS-AGT-LRx DRUG Phase PHASE2 Chronic Heart Failure With Reduced Ejection Fraction ClinicalTrials.gov
    IONIS-GHR-LRx DRUG Phase PHASE2 Acromegaly ClinicalTrials.gov
    IONIS-DMPKRx DRUG Phase PHASE1 Myotonic Dystrophy Type 1 ClinicalTrials.gov
    Somatostatin Receptor Ligand (SRL) DRUG Phase PHASE2 Acromegaly ClinicalTrials.gov
    IONIS GHR-LRx DRUG Phase PHASE2 Acromegaly ClinicalTrials.gov
    ION-682884 DRUG Phase PHASE1 Healthy Volunteers ClinicalTrials.gov
    ISIS 14803, peginterferon alfa, ribavirin DRUG Phase PHASE1 Hepatitis C, Chronic ClinicalTrials.gov
    Docetaxel DRUG Phase PHASE1 Castrate-Resistant Prostate Cancer ClinicalTrials.gov
    Prednisone DRUG Phase PHASE1 Castrate-Resistant Prostate Cancer ClinicalTrials.gov
    GHR-LRX DRUG Phase PHASE2 Acromegaly ClinicalTrials.gov
    ION224 DRUG Phase PHASE2 Steatohepatitis, Nonalcoholic ClinicalTrials.gov
    ION251 DRUG Phase PHASE1 Relapsed Multiple Myeloma ClinicalTrials.gov
    ION717 DRUG Phase PHASE1 Prion Disease ClinicalTrials.gov
    ION269 DRUG Phase PHASE1 Alzheimer Disease ClinicalTrials.gov
    IONIS MAPTRx DRUG Phase PHASE1 Mild Alzheimer's Disease ClinicalTrials.gov

    💼 Business Developments:

    • Partnership: Not available
    • Acquisition: Not available
    • Licensing: Not available
    • Regulatory Approval
    • Executive Changes: Not available

    Structured Data:

    • Company Name: Ionis Pharmaceuticals Inc
    • Ticker Symbol: IONS

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