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  • News bot Oct. 1, 2025, 9:11 p.m.

    📋 Vertex Pharmaceuticals (VRTX) - Regulatory Update

    Filing Date: 2022-05-18

    Accepted: 2022-05-18 16:01:38

    Event Type: Regulatory Update

    Event Details:

    Vertex Pharmaceuticals (VRTX) Announces Regulatory Update Vertex Pharmaceuticals (VRTX) provided an update on regulatory developments for its product portfolio. Regulatory Update Details: None Clinical Development:

    🔬 Clinical Development Pipeline (Vertex Pharmaceuticals):

    Product Type Development Stage Therapeutic Area Source
    Placebo DRUG Phase PHASE2 Proteinuric Kidney Disease ClinicalTrials.gov
    VX-147 DRUG Phase PHASE2 Proteinuric Kidney Disease ClinicalTrials.gov
    IVA DRUG Phase PHASE1 Cystic Fibrosis ClinicalTrials.gov
    VX-522 mRNA therapy DRUG Phase PHASE1 Cystic Fibrosis ClinicalTrials.gov
    VX-407 DRUG Phase PHASE2 Autosomal Dominant Polycystic Kidney Disease (ADPKD) ClinicalTrials.gov
    VNZ/TEZ/D-IVA DRUG Phase PHASE1 Cystic Fibrosis ClinicalTrials.gov
    ELX/TEZ/IVA DRUG Phase PHASE3 Cystic Fibrosis ClinicalTrials.gov
    Placebo matched to Ivacaftor DRUG Phase PHASE2 Cystic Fibrosis ClinicalTrials.gov
    Placebo matched to VX-661 DRUG Phase PHASE2 Cystic Fibrosis ClinicalTrials.gov
    Ivacaftor DRUG Phase PHASE2 Cystic Fibrosis ClinicalTrials.gov
    VX-661 DRUG Phase PHASE2 Cystic Fibrosis ClinicalTrials.gov
    Inaxaplin DRUG Phase PHASE2 Proteinuric Kidney Disease ClinicalTrials.gov
    Suzetrigine DRUG Phase PHASE4 Acute Pain ClinicalTrials.gov
    CTX001 BIOLOGICAL Phase PHASE2 Beta-Thalassemia ClinicalTrials.gov
    Povetacicept DRUG Phase PHASE1 Healthy Volunteers ClinicalTrials.gov
    Placebo (matched to VX-993) DRUG Phase PHASE2 Diabetic Peripheral Neuropathic Pain ClinicalTrials.gov
    Placebo (matched to pregabalin) DRUG Phase PHASE2 Diabetic Peripheral Neuropathic Pain ClinicalTrials.gov
    Pregabalin DRUG Phase PHASE2 Diabetic Peripheral Neuropathic Pain ClinicalTrials.gov
    VX-993 DRUG Phase PHASE2 Diabetic Peripheral Neuropathic Pain ClinicalTrials.gov
    VX-828 DRUG Phase PHASE1 Cystic Fibrosis ClinicalTrials.gov
    Deutivacaftor DRUG Phase PHASE1 Cystic Fibrosis ClinicalTrials.gov
    VX-118 DRUG Phase PHASE1 Cystic Fibrosis ClinicalTrials.gov
    Tezacaftor DRUG Phase PHASE1 Cystic Fibrosis ClinicalTrials.gov
    Midazolam DRUG Phase PHASE1 Cystic Fibrosis ClinicalTrials.gov
    Itraconazole DRUG Phase PHASE1 Cystic Fibrosis ClinicalTrials.gov
    peginterferon DRUG Phase PHASE1 Hepatitis C ClinicalTrials.gov
    VX-950 DRUG Phase PHASE1 Hepatitis C ClinicalTrials.gov
    VX-702 DRUG Phase PHASE2 Rheumatoid Arthritis ClinicalTrials.gov
    Ribavirin (Copegus®) DRUG Phase PHASE2 Hepatitis C ClinicalTrials.gov
    PEG-Interferon-alpha 2a (Pegasys®) DRUG Phase PHASE2 Hepatitis C ClinicalTrials.gov
    Merimepodib DRUG Phase PHASE2 Hepatitis C ClinicalTrials.gov
    VX-765 DRUG Phase PHASE2 Psoriasis ClinicalTrials.gov
    peginterferon alfa-2a DRUG Phase PHASE2 Hepatitis C ClinicalTrials.gov
    ribavirin DRUG Phase PHASE2 Hepatitis C ClinicalTrials.gov
    Zintevir DRUG Phase PHASE1 HIV Infections ClinicalTrials.gov
    Aroplatin (Liposomal NDDP, L-NDDP) DRUG Phase PHASE1 Esophageal Neoplasms ClinicalTrials.gov
    Aroplatin (Liposomal NDDP) in combination with capecitabine DRUG Phase PHASE1 Colorectal Neoplasms ClinicalTrials.gov
    nystatin DRUG Phase PHASE3 Chronic Myeloproliferative Disorders ClinicalTrials.gov
    amphotericin B deoxycholate DRUG Phase PHASE3 Chronic Myeloproliferative Disorders ClinicalTrials.gov
    peginterferon-alfa-2a BIOLOGICAL Phase PHASE2 Chronic Hepatitis C Virus ClinicalTrials.gov
    telaprevir DRUG Phase PHASE2 Chronic Hepatitis C Virus ClinicalTrials.gov
    VX-222 DRUG Phase PHASE2 Chronic Hepatitis C Virus ClinicalTrials.gov
    lumacaftor DRUG Phase PHASE1 Cystic Fibrosis ClinicalTrials.gov
    Pegylated Interferon Alfa-2a BIOLOGICAL Phase PHASE4 Hepatitis C ClinicalTrials.gov
    moxifloxacin hydrochloride DRUG Phase PHASE1 Cystic Fibrosis ClinicalTrials.gov
    Ivacaftor Placebo DRUG Phase PHASE1 Cystic Fibrosis ClinicalTrials.gov
    Lumacaftor Placebo DRUG Phase PHASE1 Cystic Fibrosis ClinicalTrials.gov
    Highly Active Antiretroviral Therapy (HAART) DRUG Phase PHASE3 Hepatitis C ClinicalTrials.gov
    MP-424 (Telaprevir) DRUG Phase PHASE2 Hepatitis C ClinicalTrials.gov
    VCH 916 DRUG Phase PHASE1 HCV Infection ClinicalTrials.gov
    VX-509 matching placebo DRUG Phase PHASE2 Rheumatoid Arthritis ClinicalTrials.gov
    VX-509 DRUG Phase PHASE2 Rheumatoid Arthritis ClinicalTrials.gov
    Peginterferon Alfa-2b DRUG Phase PHASE3 Hepatitis C ClinicalTrials.gov
    MP-424 DRUG Phase PHASE3 Hepatitis C ClinicalTrials.gov
    Pegylated interferon alfa 2a DRUG Phase PHASE2 Hepatitis C ClinicalTrials.gov
    Cethrin DRUG Phase PHASE1 Spinal Cord Injury ClinicalTrials.gov
    ciprofloxacin DRUG Phase PHASE1 Cystic Fibrosis ClinicalTrials.gov
    AVN944 DRUG Approved Refractory Solid Tumors ClinicalTrials.gov
    Lumacaftor Plus Ivacaftor Combination DRUG Phase PHASE3 Cystic Fibrosis, Homozygous for the F508del CFTR Mutation ClinicalTrials.gov
    VX-787 DRUG Phase PHASE2 Influenza Virus ClinicalTrials.gov
    Daclatasvir DRUG Phase PHASE2 Chronic Hepatitis C ClinicalTrials.gov
    VX-135 DRUG Phase PHASE2 Chronic Hepatitis C ClinicalTrials.gov
    Ivacaftor Exposed DRUG Preclinical Cystic Fibrosis ClinicalTrials.gov
    Ophthalmologic examinations OTHER Preclinical Cystic Fibrosis ClinicalTrials.gov
    Matching Placebo DRUG Phase PHASE2 Hepatitis C ClinicalTrials.gov
    Placebo-matched-to-ivacaftor tablet DRUG Phase PHASE2 Cystic Fibrosis ClinicalTrials.gov
    VX-809 DRUG Phase PHASE2 Cystic Fibrosis ClinicalTrials.gov
    MP-424 (L), PEG-IFN-a-2b, RBV DRUG Phase PHASE1 Hepatitis C ClinicalTrials.gov
    MP-424(H), PEG-IFN-a-2b, RBV DRUG Phase PHASE1 Hepatitis C ClinicalTrials.gov
    Immunosuppressant Regimen DRUG Phase PHASE2 Hepatitis C ClinicalTrials.gov
    VX-770 DRUG Phase PHASE2 Cystic Fibrosis ClinicalTrials.gov
    VCH-222 or matching placebo DRUG Phase PHASE1 Hepatitis C ClinicalTrials.gov
    LUM/IVA DRUG Phase PHASE3 Cystic Fibrosis ClinicalTrials.gov
    Placebo matched to VX-661/ ivacaftor DRUG Phase PHASE3 Cystic Fibrosis ClinicalTrials.gov
    VX-661/Ivacaftor DRUG Phase PHASE3 Cystic Fibrosis ClinicalTrials.gov
    Matched Placebos DRUG Phase PHASE1 Cystic Fibrosis ClinicalTrials.gov
    TEZ DRUG Phase PHASE1 Cystic Fibrosis ClinicalTrials.gov
    VX-440 DRUG Phase PHASE1 Cystic Fibrosis ClinicalTrials.gov
    de-activated smart device DEVICE Phase PHASE4 Cystic Fibrosis ClinicalTrials.gov
    activated smart device DEVICE Phase PHASE4 Cystic Fibrosis ClinicalTrials.gov
    ALS-002158 DRUG Phase PHASE1 Hepatitis C, Chronic ClinicalTrials.gov
    Placebo (matched to ivacaftor) DRUG Phase PHASE3 Cystic Fibrosis ClinicalTrials.gov
    Placebo (matched to VX-661 plus ivacaftor combination) DRUG Phase PHASE3 Cystic Fibrosis ClinicalTrials.gov
    VX-661 plus ivacaftor combination DRUG Phase PHASE3 Cystic Fibrosis ClinicalTrials.gov
    Telaprevir and Sofosbuvir DRUG Phase PHASE2 Hepatitis C, Chronic ClinicalTrials.gov
    Triple Combination (TC) Matching Placebos DRUG Phase PHASE1 Cystic Fibrosis ClinicalTrials.gov
    VX-659 Matching Placebo DRUG Phase PHASE1 Cystic Fibrosis ClinicalTrials.gov
    VX-659 DRUG Phase PHASE1 Cystic Fibrosis ClinicalTrials.gov
    VX-661 Plus Ivacaftor Combination Placebo DRUG Phase PHASE3 Cystic Fibrosis ClinicalTrials.gov
    ALS-002200 DRUG Phase PHASE1 Hepatitis C, Chronic ClinicalTrials.gov
    Tezacaftor/Ivacaftor DRUG Phase PHASE3 Cystic Fibrosis ClinicalTrials.gov
    VX-659/TEZ/IVA DRUG Phase PHASE3 Cystic Fibrosis ClinicalTrials.gov
    TEZ/IVA DRUG Phase PHASE3 Cystic Fibrosis ClinicalTrials.gov
    VX-765 Part B DRUG Phase PHASE2 Epilepsy ClinicalTrials.gov
    VX-765 Part A DRUG Phase PHASE2 Epilepsy ClinicalTrials.gov
    VX-561 DRUG Phase PHASE2 Cystic Fibrosis ClinicalTrials.gov
    VX-150 DRUG Phase PHASE2 Osteoarthritis ClinicalTrials.gov
    Peripheral blood draw PROCEDURE Phase PHASE1 Myelodysplastic Syndromes ClinicalTrials.gov
    Bone marrow biopsy PROCEDURE Phase PHASE1 Myelodysplastic Syndromes ClinicalTrials.gov
    Azacitidine DRUG Phase PHASE1 Myelodysplastic Syndromes ClinicalTrials.gov
    CX-01 DRUG Phase PHASE1 Myelodysplastic Syndromes ClinicalTrials.gov
    VX-210 DRUG Phase PHASE2 Cervical Spinal Cord Injury ClinicalTrials.gov
    VX-445/TEZ/IVA DRUG Phase PHASE3 Cystic Fibrosis ClinicalTrials.gov
    Matched Placebo DRUG Phase PHASE2 Cystic Fibrosis ClinicalTrials.gov
    Copper gluconate DRUG Phase PHASE1 Prostate Cancer ClinicalTrials.gov
    Disulfiram DRUG Phase PHASE1 Prostate Cancer ClinicalTrials.gov
    Copper DRUG Phase PHASE1 Prostate Cancer ClinicalTrials.gov
    Temozolomide (TMZ) DRUG Phase PHASE2 Recurrent Glioblastoma ClinicalTrials.gov
    Disulfiram/Copper DRUG Phase PHASE2 Recurrent Glioblastoma ClinicalTrials.gov
    Hypericin DRUG Phase PHASE1 HIV Infections ClinicalTrials.gov
    Vonoprazan, Amoxicillin, Levofloxacin DRUG Phase PHASE3 Helicobacter Pylori Infection ClinicalTrials.gov
    Questionnaires BEHAVIORAL Preclinical Cystic Fibrosis ClinicalTrials.gov
    89Zr-TLX250 PET/CT DRUG Phase PHASE2 Triple Negative Breast Cancer ClinicalTrials.gov
    Single-agent gemcitabine (Gemzar) regimen Plus Disulfiram/Copper Gluconate DRUG Phase PHASE2 Metastatic Pancreatic Cancer ClinicalTrials.gov
    FOLFIRINOX regimen Plus Disulfiram/Copper Gluconate DRUG Phase PHASE2 Metastatic Pancreatic Cancer ClinicalTrials.gov
    nab-paclitaxel (Abraxane)/gemcitabine (Gemzar) Protocol Plus Disulfiram/Copper Gluconate DRUG Phase PHASE2 Metastatic Pancreatic Cancer ClinicalTrials.gov
    Concomitant Medication Review OTHER Phase PHASE2 Metastatic Pancreatic Cancer ClinicalTrials.gov
    Physical Exam OTHER Phase PHASE2 Metastatic Pancreatic Cancer ClinicalTrials.gov
    AE Assessment OTHER Phase PHASE2 Metastatic Pancreatic Cancer ClinicalTrials.gov
    Azeliragon DRUG Phase PHASE1 Metastatic Pancreatic Cancer ClinicalTrials.gov
    ERX1000 DRUG Phase PHASE1 Obesity ClinicalTrials.gov
    Azeliragon 20 mg DRUG Phase PHASE1 Glioblastoma ClinicalTrials.gov
    Azeliragon 10 mg DRUG Phase PHASE1 Glioblastoma ClinicalTrials.gov
    Azeliragon 5 mg DRUG Phase PHASE1 Glioblastoma ClinicalTrials.gov
    124IcG250 DRUG Approved Renal Cancer ClinicalTrials.gov
    Surgery or LITT PROCEDURE Phase EARLY_PHASE1 Glioblastoma ClinicalTrials.gov
    Radiation therapy RADIATION Phase EARLY_PHASE1 Glioblastoma ClinicalTrials.gov
    Temozolomide DRUG Phase EARLY_PHASE1 Glioblastoma ClinicalTrials.gov
    VX-121/TEZ/D-IVA DRUG Phase PHASE3 Cystic Fibrosis ClinicalTrials.gov

    💼 Business Developments:

    • Partnership: Not available
    • Acquisition: Not available
    • Licensing: Not available
    • Regulatory Approval
    • Executive Changes: Not available

    Structured Data:

    • Company Name: Vertex Pharmaceuticals
    • Ticker Symbol: VRTX

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