SymbolORKA
NameORUKA THERAPEUTICS, INC.
SectorHEALTH CARE
RegionNorth America
IndustryBiotechnology: In Vitro & In Vivo Diagnostic Substances
Address11080 CIRCLEPOINT ROAD,SUITE 140, WESTMINSTER, Colorado, 80020, United States
Telephone+1 720 940-2200
Fax
Email
Websitehttps://www.orukatx.com
IncorporationUNDEFINED
Incorporated On
Employees
Fiscal Year
Public Since
ExchangesNASDAQ
Auditor
Audit StatusNOT PROVIDED
Reporting Status
CIK0000907654
Description

Oruka Therapeutics, Inc., formerly ARCA biopharma, Inc., is a biotechnology company. The Company is engaged in developing novel biologics designed for the treatment of chronic skin diseases, including plaque psoriasis. It is advancing a proprietary portfolio of potential antibodies that target the core mechanisms underlying plaque psoriasis and other dermatologic and inflammatory diseases. The Companys lead programs include ORKA-001 and ORKA-002, which are designed to block cytokines in the pathogenesis of psoriasis and other inflammatory diseases. ORKA-001 is a potentially monoclonal antibody designed to inhibit IL-23p19 for the treatment of psoriasis. ORKA-001 targets the p19 subunit of interleukin-23 (IL-23p19). ORKA-002 is a potentially monoclonal antibody designed to inhibit IL-17A/F for the treatment of psoriasis, psoriatic arthritis, and other conditions. ORKA-002 targets interleukin-17A and interleukin-17F (IL-17A/F).

Additional info from NASDAQ:
Oruka Therapeutics, Inc., formerly ARCA biopharma, Inc., is a biotechnology company. The Company is engaged in developing novel biologics designed for the treatment of chronic skin diseases, including plaque psoriasis. It is advancing a proprietary portfolio of potential antibodies that target the core mechanisms underlying plaque psoriasis and other dermatologic and inflammatory diseases. The Companys lead programs include ORKA-001 and ORKA-002, which are designed to block cytokines in the pathogenesis of psoriasis and other inflammatory diseases. ORKA-001 is a potentially monoclonal antibody designed to inhibit IL-23p19 for the treatment of psoriasis. ORKA-001 targets the p19 subunit of interleukin-23 (IL-23p19). ORKA-002 is a potentially monoclonal antibody designed to inhibit IL-17A/F for the treatment of psoriasis, psoriatic arthritis, and other conditions. ORKA-002 targets interleukin-17A and interleukin-17F (IL-17A/F).

2026-08-17 22:09

Goncalves Joana 🟡 adjusted position in 7.0K shares (2 derivative) of Oruka Therapeutics, Inc. (ORKA) at $112.56 Transaction Date: Aug 17, 2026 | Filing ID: 000079

Read more
2026-08-14 21:52

Quinlan Paul T 🟡 adjusted position in 52.0K shares (2 derivative) of Oruka Therapeutics, Inc. (ORKA) at $111.14 ($6.8M) Transaction Date: Aug 14, 2026 | Filing ID: 000077

Read more
2026-08-14 21:42

Agarwal Arjun 🟡 adjusted position in 10.0K shares (2 derivative) of Oruka Therapeutics, Inc. (ORKA) at $108.46 ($1.4M) Transaction Date: Aug 13, 2026 | Filing ID: 000075

Read more
2026-08-14 20:39

📋 PAUL QUINLAN (Officer) plans to sell 71K shares of Oruka Therapeutics, Inc. (at $108.12 each, total $7.7M) Filed: Aug 14, 2026 | ID: 008164

Read more
2026-08-14 17:55

New Form SCHEDULE 13G/A - Oruka Therapeutics, Inc. <b>Filed:</b> 2026-08-14 <b>AccNo:</b> 0001231919-26-000934 <b>Size:</b> 18 KB

Read more
2026-08-14 17:17

New Form SCHEDULE 13G/A - Oruka Therapeutics, Inc. <b>Filed:</b> 2026-08-14 <b>AccNo:</b> 0000905148-26-003735 <b>Size:</b> 36 KB

Read more
2026-08-14 09:05

New Form SCHEDULE 13G - Oruka Therapeutics, Inc. <b>Filed:</b> 2026-08-14 <b>AccNo:</b> 0001493215-26-000153 <b>Size:</b> 12 KB

Read more
2026-08-10 11:03

Oruka Therapeutics Reports Second Quarter 2026 Financial Results and Provides Corporate Update

Read more
2026-08-10 11:00

(30% Negative) ORUKA THERAPEUTICS, INC. (ORKA) Reports Q3 2026 Financial Results

Read more
2026-07-15 23:36

Goncalves Joana 🟡 adjusted position in 7.0K shares (2 derivative) of Oruka Therapeutics, Inc. (ORKA) at $87.25 Transaction Date: Jul 15, 2026 | Filing ID: 000073

Read more
Trial ID Title Phase Indication Status Start Date Completion Date Source
NCT07474792 Dose Ranging Study of ORKA-002 in Patients With Moderate-to-Severe Plaque Psori… Phase2 Plaque Psoriasis Recruiting 2026-03-19 2029-04-01 ClinicalTrials.gov
NCT07449702 An Open-Label Extension Study of ORKA-001 in Participants With Plaque Psoriasis Phase2 Plaque Psoriasis Recruiting 2026-02-23 2030-07-01 ClinicalTrials.gov
NCT07290569 Dose Ranging Study of ORKA-001 in Patients With Moderate-to-Severe Plaque Psori… Phase2 Plaque Psoriasis Active_Not_Recruiting 2025-12-03 2028-12-01 ClinicalTrials.gov
NCT07090330 ORKA-001 Versus Placebo in Patients With Moderate-to-Severe Plaque Psoriasis Phase2 Plaque Psoriasis Active_Not_Recruiting 2025-07-18 2027-05-01 ClinicalTrials.gov
NCT06944379 ORKA-002-211 A Phase I Study to Evaluate ORKA-002 in Healthy Volunteers Followi… Phase1 Healthy Volunteers Active_Not_Recruiting 2025-05-19 2027-01-01 ClinicalTrials.gov
NCT06698939 ORKA-001 in Healthy Volunteers Phase1 Healthy Volunteers Completed 2024-12-19 2026-03-13 ClinicalTrials.gov
Total clinical trials: 6
Product Name Type Development Stage Therapeutic Area Study Status Trial ID
Placebo Other Phase PHASE2 Plaque Psoriasis ACTIVE_NOT_RECRUITING NCT07290569
ORKA-001 Other Phase PHASE2 Plaque Psoriasis ACTIVE_NOT_RECRUITING NCT07290569
Placebo Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
ORKA-002 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
ORKA-001 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07449702
Placebo Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
ORKA-002 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
Placebo Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07290569
ORKA-001 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07290569
ORKA-001 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07449702
ORKA-001 Maintenance Dose Other Phase PHASE2 Plaque Psoriasis ACTIVE_NOT_RECRUITING NCT07090330
Placebo Other Phase PHASE2 Plaque Psoriasis ACTIVE_NOT_RECRUITING NCT07090330
ORKA-001 Induction Dose Other Phase PHASE2 Plaque Psoriasis ACTIVE_NOT_RECRUITING NCT07090330
ORKA-001 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07449702
Placebo Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07290569
ORKA-001 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07290569
Placebo Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
ORKA-002 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
Placebo Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
ORKA-002 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
Placebo Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
ORKA-002 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
Placebo Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
ORKA-002 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
Placebo Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
ORKA-002 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
Placebo Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
ORKA-002 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
Placebo Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
ORKA-002 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
ORKA-001 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07449702
ORKA-001 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07449702
ORKA-001 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07449702
ORKA-001 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07449702
ORKA-001 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07449702
ORKA-001 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07449702
ORKA-001 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07449702
ORKA-001 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07449702
ORKA-001 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07449702
ORKA-001 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07449702
ORKA-001 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07449702
ORKA-001 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07449702
ORKA-001 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07449702
ORKA-001 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07449702
ORKA-001 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07449702
ORKA-001 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07449702
Placebo Other Phase PHASE1 Healthy Volunteers ACTIVE_NOT_RECRUITING NCT06944379
ORKA-002 Other Phase PHASE1 Healthy Volunteers ACTIVE_NOT_RECRUITING NCT06944379
ORKA-001 Maintenance Dose Other Phase PHASE2 Plaque Psoriasis ACTIVE_NOT_RECRUITING NCT07090330
Placebo Other Phase PHASE2 Plaque Psoriasis ACTIVE_NOT_RECRUITING NCT07090330
ORKA-001 Induction Dose Other Phase PHASE2 Plaque Psoriasis ACTIVE_NOT_RECRUITING NCT07090330
Placebo Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07290569
ORKA-001 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07290569
Placebo Other Phase PHASE1 Healthy Volunteers COMPLETED NCT06698939
ORKA-001 Other Phase PHASE1 Healthy Volunteers COMPLETED NCT06698939
Placebo Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
ORKA-002 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
ORKA-001 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07449702
ORKA-001 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07449702
Placebo Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
ORKA-002 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
ORKA-001 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07449702
Placebo Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
ORKA-002 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
ORKA-001 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07449702
Placebo Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
ORKA-002 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
ORKA-001 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07449702
Placebo Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
ORKA-002 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
ORKA-001 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07449702
Placebo Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
ORKA-002 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
ORKA-001 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07449702
Placebo Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
ORKA-002 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
ORKA-001 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07449702
Placebo Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
ORKA-002 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
ORKA-001 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07449702
Placebo Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
ORKA-002 Other Phase PHASE2 Plaque Psoriasis RECRUITING NCT07474792
ORKA-001 Maintenance Dose DRUG Phase PHASE2 Plaque Psoriasis ACTIVE_NOT_RECRUITING NCT07090330
ORKA-001 Induction Dose DRUG Phase PHASE2 Plaque Psoriasis ACTIVE_NOT_RECRUITING NCT07090330
ORKA-002 DRUG Phase PHASE2 Plaque Psoriasis NOT_YET_RECRUITING NCT07474792
Placebo OTHER Phase PHASE2 Plaque Psoriasis NOT_YET_RECRUITING NCT07474792
ORKA-001 DRUG Phase PHASE2 Plaque Psoriasis RECRUITING NCT07449702
Total products: 87