SymbolNXTC
NameNEXTCURE, INC.
SectorHEALTH CARE
RegionNorth America
IndustryBiotechnology: Pharmaceutical Preparations
Address9000 VIRGINIA MANOR ROAD,SUITE 200, BELTSVILLE, Maryland, 20705, United States
Telephone+1 240 - 399-4900
Fax
Email
Websitehttps://www.nextcure.com
IncorporationUNDEFINED
Incorporated On
Employees
Fiscal Year
Public Since
ExchangesNASDAQ
Auditor
Audit StatusNOT PROVIDED
Reporting Status
CIK0001661059
Description

NextCure Inc is a clinical-stage biopharmaceutical company committed to discovering and developing immunomedicines to treat cancer and other immune-related diseases by restoring normal immune function. It is focused on understanding biological pathways, the interactions of cells and the role each interaction plays in an immune response. The companys product candidate, NC318, is an immunomedicine against an immunomodulatory receptor called Siglec-15, or S15.

Additional info from NASDAQ:
NextCure Inc is a clinical-stage biopharmaceutical company committed to discovering and developing immunomedicines to treat cancer and other immune-related diseases by restoring normal immune function. It is focused on understanding biological pathways, the interactions of cells and the role each interaction plays in an immune response. The companys product candidate, NC318, is an immunomedicine against an immunomodulatory receptor called Siglec-15, or S15.

2026-06-04 12:00

NXTC Announces Replay Available for Virtual KOL Event Discussing ASCO 2026 Dose Escalation Data from Phase 1 Trial of SIM0505 for Gynecologic Cancers

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2026-06-01 12:00

NextCure Presents Positive SIM0505 Phase 1 Dose Escalation Data in Patients with Gynecologic Cancers at ASCO 2026

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2026-05-13 17:42

New Form SCHEDULE 13G/A - NextCure, Inc. <b>Filed:</b> 2026-05-13 <b>AccNo:</b> 0001104659-26-060317 <b>Size:</b> 8 KB

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2026-05-07 20:19

(85% Positive) NEXTCURE, INC. (NXTC) Reports Q2 2026 Financial Results

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2026-05-07 20:05

NextCure Provides Business Update and Reports First Quarter 2026 Financial Results

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2026-05-06 22:27

New Form SCHEDULE 13G/A - NextCure, Inc. <b>Filed:</b> 2026-05-06 <b>AccNo:</b> 0001213900-26-052993 <b>Size:</b> 20 KB

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2026-05-04 11:05

NextCure and Simcere Zaiming Initiate Dose Optimization for SIM0505 (CDH6 ADC) in Gynecologic Cancers

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2026-04-24 17:19

New Form DEFA14A - NextCure, Inc. <b>Filed:</b> 2026-04-24 <b>AccNo:</b> 0001104659-26-048606 <b>Size:</b> 383 KB

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2026-04-24 17:16

New Form DEF 14A - NextCure, Inc. <b>Filed:</b> 2026-04-24 <b>AccNo:</b> 0001104659-26-048591 <b>Size:</b> 4 MB

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2026-04-21 14:15

NextCure and Simcere’s SIM0505 (CDH6 ADC) Phase 1 Data to be Presented at ASCO 2026

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Trial ID Title Phase Indication Status Start Date Completion Date Source
NCT06941857 NC410 and FOLFIRINOX in Combination With Nivolumab With or Without Ipilimumab i… Phase2 Pancreatic Cancer Recruiting 2025-09-04 2028-12-01 ClinicalTrials.gov
NCT06792552 A Phase I Study of SIM0505 in Participants With Advanced Solid Tumors Phase1 Advanced Solid Tumors Recruiting 2025-02-26 2028-08-01 ClinicalTrials.gov
NCT06774963 A Phase 1 Study of LNCB74 in Advanced Solid Tumors Phase1 Ovarian Cancer Recruiting 2025-01-07 2026-12-01 ClinicalTrials.gov
NCT05787496 A Safety, Tolerability and Efficacy Study of NC525 in Subjects With Advanced My… Phase1 Relapsed or Refractory Acute Myeloid Leukemia Terminated 2023-02-28 2025-01-31 ClinicalTrials.gov
NCT05572684 A Safety, Tolerability and Efficacy Study of NC410 Plus Pembrolizumab in Partic… Phase1 Advanced or Metastatic Solid Tumors Active_Not_Recruiting 2022-10-06 2025-11-01 ClinicalTrials.gov
NCT04430933 A Safety and Tolerability Study of NC318 in Combination With Chemotherapy for S… Phase1 Advanced or Metastatic Solid Tumors Withdrawn 2021-12-06 2022-10-30 ClinicalTrials.gov
NCT04875806 A Safety and Tolerability Study of NC762 in Subjects With Advanced or Metastati… Phase1 Advanced or Metastatic Solid Tumors Terminated 2021-06-30 2024-01-30 ClinicalTrials.gov
NCT04699123 The Study of NC318 Alone or in Combination With Pembrolizumab in Patients With … Phase2 Advanced Non-small Cell Lung Cancer Active_Not_Recruiting 2021-02-04 2025-06-30 ClinicalTrials.gov
NCT04408599 A Safety and Tolerability Study of NC410 in Subjects With Advanced or Metastati… Phase1 Advanced or Metastatic Solid Tumors Terminated 2020-06-10 2023-07-06 ClinicalTrials.gov
NCT03665285 A Safety and Tolerability Study of NC318 in Subjects With Advanced or Metastati… Phase1 Advanced or Metastatic Solid Tumors Completed 2018-10-01 2023-04-11 ClinicalTrials.gov
Total clinical trials: 10
Product Name Type Development Stage Therapeutic Area Study Status Trial ID
Ipilimumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Nivolumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
NC410 Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
5-Fluorouracil (5-FU) Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Folinic Acid Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Irinotecan Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Oxaliplatin Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Ipilimumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Nivolumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
NC410 Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
5-Fluorouracil (5-FU) Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Folinic Acid Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Irinotecan Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Oxaliplatin Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Ipilimumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Nivolumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
NC410 Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
5-Fluorouracil (5-FU) Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Folinic Acid Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Irinotecan Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Oxaliplatin Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Ipilimumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Nivolumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
NC410 Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
5-Fluorouracil (5-FU) Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Folinic Acid Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Irinotecan Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Oxaliplatin Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Ipilimumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Nivolumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
NC410 Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
5-Fluorouracil (5-FU) Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Folinic Acid Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Irinotecan Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Oxaliplatin Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Ipilimumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Nivolumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
NC410 Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
5-Fluorouracil (5-FU) Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Folinic Acid Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Irinotecan Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Oxaliplatin Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Ipilimumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Nivolumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
NC410 Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
5-Fluorouracil (5-FU) Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Folinic Acid Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Irinotecan Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Oxaliplatin Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Ipilimumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Nivolumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
NC410 Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
5-Fluorouracil (5-FU) Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Folinic Acid Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Irinotecan Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Oxaliplatin Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Ipilimumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Nivolumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
NC410 Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
5-Fluorouracil (5-FU) Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Folinic Acid Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Irinotecan Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Oxaliplatin Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Ipilimumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Nivolumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
NC410 Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
5-Fluorouracil (5-FU) Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Folinic Acid Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Irinotecan Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Oxaliplatin Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Ipilimumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Nivolumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
NC410 Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
5-Fluorouracil (5-FU) Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Folinic Acid Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Irinotecan Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Oxaliplatin Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Ipilimumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Nivolumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
NC410 Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
5-Fluorouracil (5-FU) Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Folinic Acid Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Irinotecan Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Oxaliplatin Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Ipilimumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Nivolumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
NC410 Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
5-Fluorouracil (5-FU) Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Folinic Acid Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Irinotecan Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Oxaliplatin Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Ipilimumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Nivolumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
NC410 Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
5-Fluorouracil (5-FU) Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Folinic Acid Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Irinotecan Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Oxaliplatin Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Ipilimumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Nivolumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
NC410 Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
5-Fluorouracil (5-FU) Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Folinic Acid Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Irinotecan Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Oxaliplatin Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Ipilimumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Nivolumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
NC410 Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
5-Fluorouracil (5-FU) Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Folinic Acid Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Irinotecan Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Oxaliplatin Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Ipilimumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Nivolumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
NC410 Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
5-Fluorouracil (5-FU) Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Folinic Acid Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Irinotecan Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Oxaliplatin Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
NC762 Other Phase PHASE1 Advanced or Metastatic Solid Tumors TERMINATED NCT04875806
Docetaxel Other Phase PHASE1 Advanced or Metastatic Solid Tumors WITHDRAWN NCT04430933
Nab paclitaxel/Carboplatin Other Phase PHASE1 Advanced or Metastatic Solid Tumors WITHDRAWN NCT04430933
Pemetrexed/Carboplatin Other Phase PHASE1 Advanced or Metastatic Solid Tumors WITHDRAWN NCT04430933
NC318 Other Phase PHASE1 Advanced or Metastatic Solid Tumors WITHDRAWN NCT04430933
NC318 Other Phase PHASE1 Advanced or Metastatic Solid Tumors COMPLETED NCT03665285
NC410 Other Phase PHASE1 Advanced or Metastatic Solid Tumors TERMINATED NCT04408599
pembrolizumab Other Phase PHASE1 Advanced or Metastatic Solid Tumors ACTIVE_NOT_RECRUITING NCT05572684
NC410 Other Phase PHASE1 Advanced or Metastatic Solid Tumors ACTIVE_NOT_RECRUITING NCT05572684
Pembrolizumab Other Phase PHASE2 Advanced Non-small Cell Lung Cancer ACTIVE_NOT_RECRUITING NCT04699123
NC318 400 mg Other Phase PHASE2 Advanced Non-small Cell Lung Cancer ACTIVE_NOT_RECRUITING NCT04699123
NC318 800 mg Other Phase PHASE2 Advanced Non-small Cell Lung Cancer ACTIVE_NOT_RECRUITING NCT04699123
LNCB74 Other Phase PHASE1 Ovarian Cancer RECRUITING NCT06774963
NC525 Other Phase PHASE1 Relapsed or Refractory Acute Myeloid Leukemia TERMINATED NCT05787496
Ipilimumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Nivolumab Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
NC410 Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
5-Fluorouracil (5-FU) Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Folinic Acid Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Irinotecan Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Oxaliplatin Other Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
SIM0505 for injection Other Phase PHASE1 Advanced Solid Tumors RECRUITING NCT06792552
Ipilimumab DRUG Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Nivolumab DRUG Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
5-Fluorouracil (5-FU) DRUG Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Folinic Acid DRUG Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Irinotecan DRUG Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
Oxaliplatin DRUG Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
SIM0505 for injection DRUG Phase PHASE1 Advanced Solid Tumors RECRUITING NCT06792552
LNCB74 DRUG Phase PHASE1 Ovarian Cancer RECRUITING NCT06774963
NC525 DRUG Phase PHASE1 Relapsed or Refractory Acute Myeloid Leukemia TERMINATED NCT05787496
pembrolizumab DRUG Phase PHASE1 Advanced or Metastatic Solid Tumors ACTIVE_NOT_RECRUITING NCT05572684
NC762 DRUG Phase PHASE1 Advanced or Metastatic Solid Tumors TERMINATED NCT04875806
Pembrolizumab DRUG Phase PHASE2 Advanced Non-small Cell Lung Cancer ACTIVE_NOT_RECRUITING NCT04699123
NC318 400 mg DRUG Phase PHASE2 Advanced Non-small Cell Lung Cancer ACTIVE_NOT_RECRUITING NCT04699123
NC318 800 mg DRUG Phase PHASE2 Advanced Non-small Cell Lung Cancer ACTIVE_NOT_RECRUITING NCT04699123
Docetaxel DRUG Phase PHASE1 Advanced or Metastatic Solid Tumors WITHDRAWN NCT04430933
Nab paclitaxel/Carboplatin DRUG Phase PHASE1 Advanced or Metastatic Solid Tumors WITHDRAWN NCT04430933
Pemetrexed/Carboplatin DRUG Phase PHASE1 Advanced or Metastatic Solid Tumors WITHDRAWN NCT04430933
NC410 DRUG Phase PHASE2 Pancreatic Cancer RECRUITING NCT06941857
NC318 DRUG Phase PHASE1 Advanced or Metastatic Solid Tumors WITHDRAWN NCT04430933
Total products: 160