SymbolCNTA
NameCENTESSA PHARMACEUTICALS PLC
SectorHEALTH CARE
RegionEurope
IndustryBiotechnology: Pharmaceutical Preparations
Address1 ASHLEY ROAD,3RD FLOOR, CHESHIRE, WA14 2DT, United Kingdom
Telephone+44 2039206789
Fax
Email
Websitehttps://www.centessa.com
IncorporationUNDEFINED
Incorporated On
Employees
Fiscal Year
Public Since
ExchangesNASDAQ
Auditor
Audit StatusNOT PROVIDED
Reporting Status
CIK0001847903
Description

Centessa Pharmaceuticals PLC is a pharmaceutical company. Its portfolio consists of preclinical to phase 3 uncorrelated programs spanning diseases with high unmet need across oncology, hematology, immunology, inflammation, neuroscience, and rare diseases. Some of its products include Vasopressin V2 Receptor Inhibitor (Lixivaptan), BMP9 Engineered Variant (MGX292), OX2R Agonist (Oral) among others.

Additional info from NASDAQ:
Centessa Pharmaceuticals PLC is a pharmaceutical company. Its portfolio consists of preclinical to phase 3 uncorrelated programs spanning diseases with high unmet need across oncology, hematology, immunology, inflammation, neuroscience, and rare diseases. Some of its products include Vasopressin V2 Receptor Inhibitor (Lixivaptan), BMP9 Engineered Variant (MGX292), OX2R Agonist (Oral) among others.

2026-04-29 09:03

New Form ARS - Centessa Pharmaceuticals plc <b>Filed:</b> 2026-04-29 <b>AccNo:</b> 0001847903-26-000041 <b>Size:</b> 27 MB

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2026-04-29 09:00

New Form DEF 14A - Centessa Pharmaceuticals plc <b>Filed:</b> 2026-04-29 <b>AccNo:</b> 0001847903-26-000040 <b>Size:</b> 2 MB

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2026-04-13 18:27

New Form DEFA14A - Centessa Pharmaceuticals plc <b>Filed:</b> 2026-04-13 <b>AccNo:</b> 0001193125-26-153121 <b>Size:</b> 32 KB

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2026-04-01 20:14

SHAREHOLDER ALERT: The M&A Class Action Firm Announces An Investigation of Centessa Pharmaceuticals plc (NASDAQ: CNTA)

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2026-04-01 02:19

Centessa Pharmaceuticals Investor Alert: Kahn Swick & Foti, LLC Investigates Adequacy of Price and Process in Proposed Sale of Centessa Pharmaceuticals plc - CNTA

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2026-03-31 20:21

(10% Negative) CENTESSA PHARMACEUTICALS PLC (CNTA) Announces Business Combination

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2026-03-31 17:39

New Form DEFA14A - Centessa Pharmaceuticals plc <b>Filed:</b> 2026-03-31 <b>AccNo:</b> 0001193125-26-134758 <b>Size:</b> 46 KB

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2026-03-31 17:37

New Form DEFA14A - Centessa Pharmaceuticals plc <b>Filed:</b> 2026-03-31 <b>AccNo:</b> 0001193125-26-134750 <b>Size:</b> 23 KB

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2026-03-31 17:35

New Form DEFA14A - Centessa Pharmaceuticals plc <b>Filed:</b> 2026-03-31 <b>AccNo:</b> 0001193125-26-134740 <b>Size:</b> 25 KB

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2026-03-31 17:33

New Form DEFA14A - Centessa Pharmaceuticals plc <b>Filed:</b> 2026-03-31 <b>AccNo:</b> 0001193125-26-134727 <b>Size:</b> 28 KB

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Trial ID Title Phase Indication Status Start Date Completion Date Source
NCT07413666 A Study of ORX489 in Healthy Adult Participants, Aged 18 to 60 Years Phase1 Healthy Adult Male and Female Volunteers Recruiting 2026-02-25 2027-06-30 ClinicalTrials.gov
NCT07096674 A Long-term Extension Study of ORX750 in Participants With Narcolepsy and Idiop… Phase2 Narcolepsy Type 1 Recruiting 2025-08-12 2026-04-30 ClinicalTrials.gov
NCT07082829 A Study of ORX142 in Healthy Adult Subjects, Including Subjects 18 to 80 Years … Phase1 Excessive Daytime Sleepiness Recruiting 2025-06-30 2026-06-15 ClinicalTrials.gov
NCT06752668 A Study of ORX750 in Participants With Narcolepsy and Idiopathic Hypersomnia Phase2 Narcolepsy Type 1 Recruiting 2024-12-23 2026-12-01 ClinicalTrials.gov
NCT06568302 The Long-term Safety and Efficacy of SerpinPC in Subjects with Hemophilia Who C… Phase3 Hemophilia a Terminated 2024-07-11 2025-01-29 ClinicalTrials.gov
NCT05789537 A Study of SerpinPC in Participants with Hemophilia B (HemB) with Inhibitors Phase2 Hemophilia B with Inhibitor Terminated 2023-07-28 2025-02-24 ClinicalTrials.gov
NCT05789524 The Efficacy and Safety of SerpinPC in Participants with Severe Hemophilia a or… Phase2 Hemophilia a Terminated 2023-07-06 2025-02-28 ClinicalTrials.gov
NCT05821777 A Study to Evaluate Safety, Tolerability and Preliminary Activity of LB101 in P… Phase1 Advanced Solid Tumor Terminated 2023-03-28 2025-09-09 ClinicalTrials.gov
NCT05605678 Hemophilia Non-Interventional Study Prior to SerpinPC Intervention (PRESent-5) Hemophilia a Terminated 2022-12-09 2024-11-29 ClinicalTrials.gov
NCT05323110 Study of Intravenously Administered Anti-LIGHT Monoclonal Antibody CBS001 in He… Phase1 Chronic Inflammatory Disease Terminated 2022-04-14 2023-08-22 ClinicalTrials.gov
NCT05208866 Roll-over Study to Assess Safety of Lixivaptan in Participants With ADPKD Who C… Phase3 Polycystic Kidney Disease, Adult Terminated 2022-02-10 2022-07-29 ClinicalTrials.gov
NCT04064346 Efficacy and Safety of Lixivaptan in the Treatment of Autosomal Dominant Polycy… Phase3 Autosomal Dominant Polycystic Kidney Terminated 2021-10-28 2022-08-03 ClinicalTrials.gov
NCT04152837 Safety of Lixivaptan in Subjects Previously Treated With Tolvaptan for Autosoma… Phase3 Polycystic Kidney Disease, Adult Terminated 2020-09-02 2022-07-29 ClinicalTrials.gov
NCT04443192 A Single Ascending and Repeated Dose Study of Oral ZF874 in Healthy Volunteers … Phase1 Alpha1 Anti-Trypsin Deficiency Terminated 2020-08-03 2022-09-12 ClinicalTrials.gov
NCT04073498 The Safety and Tolerability of SerpinPC in Healthy Men and in Men with Severe B… Phase1 Hemophilia a Completed 2019-08-14 2024-09-26 ClinicalTrials.gov
Total clinical trials: 15
Product Name Type Development Stage Therapeutic Area Study Status Trial ID
Placebo Other Phase PHASE1 Alpha1 Anti-Trypsin Deficiency TERMINATED NCT04443192
ZF874 Other Phase PHASE1 Alpha1 Anti-Trypsin Deficiency TERMINATED NCT04443192
Placebo Other Phase PHASE3 Autosomal Dominant Polycystic Kidney TERMINATED NCT04064346
Lixivaptan Other Phase PHASE3 Autosomal Dominant Polycystic Kidney TERMINATED NCT04064346
Lixivaptan Other Phase PHASE3 Polycystic Kidney Disease, Adult TERMINATED NCT04152837
Lixivaptan Other Phase PHASE3 Polycystic Kidney Disease, Adult TERMINATED NCT05208866
Placebo Other Phase PHASE1 Chronic Inflammatory Disease TERMINATED NCT05323110
CBS001 Other Phase PHASE1 Chronic Inflammatory Disease TERMINATED NCT05323110
Placebo Other Phase PHASE1 Hemophilia a COMPLETED NCT04073498
SerpinPC Other Phase PHASE1 Hemophilia a COMPLETED NCT04073498
No Intervention Other Preclinical Hemophilia a TERMINATED NCT05605678
SerpinPC Other Phase PHASE3 Hemophilia a TERMINATED NCT06568302
SerpinPC Other Phase PHASE2 Hemophilia B with Inhibitor TERMINATED NCT05789537
SerpinPC Other Phase PHASE2 Hemophilia a TERMINATED NCT05789524
LB101 Other Phase PHASE1 Advanced Solid Tumor TERMINATED NCT05821777
LB101 Other Phase PHASE1 Advanced Solid Tumor TERMINATED NCT05821777
Placebo Tablets Other Phase PHASE1 Excessive Daytime Sleepiness RECRUITING NCT07082829
ORX142 Tablets Other Phase PHASE1 Excessive Daytime Sleepiness RECRUITING NCT07082829
Placebo Tablets Other Phase PHASE1 Excessive Daytime Sleepiness RECRUITING NCT07082829
ORX142 Tablets Other Phase PHASE1 Excessive Daytime Sleepiness RECRUITING NCT07082829
Placebo Tablets Other Phase PHASE1 Healthy Adult Male and Female Volunteers RECRUITING NCT07413666
ORX489 Tablets Other Phase PHASE1 Healthy Adult Male and Female Volunteers RECRUITING NCT07413666
Placebo Tablets Other Phase PHASE1 Healthy Adult Male and Female Volunteers RECRUITING NCT07413666
ORX489 Tablets Other Phase PHASE1 Healthy Adult Male and Female Volunteers RECRUITING NCT07413666
ORX750 Other Phase PHASE2 Narcolepsy Type 1 RECRUITING NCT07096674
ORX750 Other Phase PHASE2 Narcolepsy Type 1 RECRUITING NCT07096674
ORX750 Other Phase PHASE2 Narcolepsy Type 1 RECRUITING NCT07096674
Placebo Other Phase PHASE2 Narcolepsy Type 1 RECRUITING NCT06752668
ORX750 Other Phase PHASE2 Narcolepsy Type 1 RECRUITING NCT06752668
Placebo Other Phase PHASE2 Narcolepsy Type 1 RECRUITING NCT06752668
ORX750 Other Phase PHASE2 Narcolepsy Type 1 RECRUITING NCT06752668
Placebo Other Phase PHASE2 Narcolepsy Type 1 RECRUITING NCT06752668
ORX750 Other Phase PHASE2 Narcolepsy Type 1 RECRUITING NCT06752668
Placebo Other Phase PHASE2 Narcolepsy Type 1 RECRUITING NCT06752668
ORX750 Other Phase PHASE2 Narcolepsy Type 1 RECRUITING NCT06752668
Placebo Other Phase PHASE2 Narcolepsy Type 1 RECRUITING NCT06752668
ORX750 Other Phase PHASE2 Narcolepsy Type 1 RECRUITING NCT06752668
Placebo Other Phase PHASE2 Narcolepsy Type 1 RECRUITING NCT06752668
ORX750 Other Phase PHASE2 Narcolepsy Type 1 RECRUITING NCT06752668
Placebo Other Phase PHASE2 Narcolepsy Type 1 RECRUITING NCT06752668
ORX750 Other Phase PHASE2 Narcolepsy Type 1 RECRUITING NCT06752668
Placebo Other Phase PHASE2 Narcolepsy Type 1 RECRUITING NCT06752668
ORX750 Other Phase PHASE2 Narcolepsy Type 1 RECRUITING NCT06752668
ORX750 Other Phase PHASE2 Narcolepsy Type 1 RECRUITING NCT07096674
ORX750 Other Phase PHASE2 Narcolepsy Type 1 RECRUITING NCT07096674
ORX750 Other Phase PHASE2 Narcolepsy Type 1 RECRUITING NCT07096674
LB101 DRUG Phase PHASE1 Advanced Solid Tumor TERMINATED NCT05821777
ORX142 Tablets DRUG Phase PHASE1 Excessive Daytime Sleepiness RECRUITING NCT07082829
Placebo Tablets OTHER Phase PHASE1 Excessive Daytime Sleepiness RECRUITING NCT07082829
ORX489 Tablets DRUG Phase PHASE1 Healthy Adult Male and Female Volunteers RECRUITING NCT07413666
ORX750 DRUG Phase PHASE2 Narcolepsy Type 1 RECRUITING NCT06752668
No Intervention OTHER Preclinical Hemophilia a TERMINATED NCT05605678
CBS001 DRUG Phase PHASE1 Chronic Inflammatory Disease TERMINATED NCT05323110
ZF874 DRUG Phase PHASE1 Alpha1 Anti-Trypsin Deficiency TERMINATED NCT04443192
SerpinPC DRUG Phase PHASE3 Hemophilia a TERMINATED NCT06568302
Placebo DRUG Phase PHASE2 Narcolepsy Type 1 RECRUITING NCT06752668
Lixivaptan DRUG Phase PHASE3 Polycystic Kidney Disease, Adult TERMINATED NCT05208866
Total products: 57